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Cyclophosphamide, Velcade® and Dexamethasone (CVD) and AL amyloidosis Infoguide

This Infoguide provides information about cyclophosphamide, Velcade and dexamethasone (CVD), one of the treatment combinations used in AL amyloidosis.

This Infoguide provides information about cyclophosphamide, Velcade and dexamethasone (CVD), one of the treatment combinations used in AL amyloidosis.

This Infoguide aims to:

  • Provide you with more information about CVD as a treatment for AL amyloidosis
  • Answer some of the questions you may have about CVD
  • Provides a lis ofs some questions that you should ask your doctor or medical team.
  • Help you to make informed decisions about the treatment options available to you

CVD is often referred to as ‘chemotherapy’ or ‘chemo’, but it is a combination of three different drugs:

  • Cyclophosphamide
  • Velcade
  • Dexamethasone

These three drugs have a different but synergistic and complementary mechanisms of action. This means they work in
diff erent ways but they are much more effective at destroying abnormal plasma cells in the bone marrow than if they were given alone.

Cyclophosphamide is a chemotherapy drug. The term chemotherapy is derived from the words ‘chemical’ and ‘therapy’ and is the name used to describe a range of drugs aimed at killing cancer cells and other fast growing abnormal cells.

Cyclophosphamide is usually given orally (in tablet form) when used in the CVD combination. As with all drugs, cyclophosphamide has a number of possible side-effects. These vary considerably from patient to patient; what might be mild in one person can be more serious in another.

Velcade (also known as bortezomib) belongs to a class of drugs called proteasome inhibitors. Velcade can be given
intravenously (into the vein) or as a subcutaneous (under the skin) injection.

Velcade has a number of possible side effects, which can usually be treated or managed.

Dexamethasone is a synthetic steroid which acts like a naturally occurring hormone produced in the body. In AL amyloidosis dexamethasone is used to suppress inflammation and the immune response.

Dexamethasone has a number of possible side effects. Some of these vary according to the dose, with
increasing side effects associated with higher doses.

The infosheet also lists some questions that you should ask your doctor or medical team.