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Monoclonal Gammopathy of Undetermined Significance (MGUS) Infosheet

This Infosheet explains what Monoclonal Gammopathy of Undetermined Significance (MGUS) is and how it is diagnosed and managed.

Monoclonal gammopathy of undetermined significance, or ‘MGUS’, is a benign (noncancerous) condition.

Unlike myeloma, there are no symptoms associated with MGUS and it does not require treatment. Generally, any symptoms that MGUS patients have are associated with other medical problems.

However, MGUS patients need to look out for any new symptoms that might indicate the development of a more
serious diagnosis, such as myeloma. Common signs and symptoms of myeloma include bone pain, kidney damage,
fatigue and being prone to recurring infection.

It is not yet clear why only a small minority of patients progress to myeloma and, unfortunately, when MGUS is
diagnosed no definitive test exists that shows who will progress to myeloma and who will remain stable long-term.

Ongoing research aims to better understand what influences the progression of MGUS to myeloma.