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Solitary plasmacytoma Infosheet

This Infosheet explains what a solitary plasmacytoma is, what causes one, what the signs and symptoms are, what diagnosis involves and how they are treated.

A plasmacytoma is a localised build-up of abnormal plasma cells that occurs either inside bone or within the soft tissue.

Plasmacytomas can occur as a feature of a plasma cell cancer called myeloma.

A plasmacytoma can also exist as a discreet, single mass of abnormal plasma cells – this is called a solitary plasmacytoma.

A solitary plasmacytoma found inside the bone is called a solitary bone plasmacytoma (SBP). One found outside the bone, in the soft tissue, is called a solitary extramedullary plasmacytoma (SEP).

Some patients diagnosed with a solitary plasmacytoma will go on to develop myeloma. In general, the risk of progression
to myeloma is higher in patients with an SBP compared to those with an SEP.

This infosheet covers the signs and symptoms of solitary plasmacytoma, as well as how a diagnosis is made.

The most common treatment for both types of solitary plasmacytoma is radiotherapy. Chemotherapy is not commonly used though in some cases of SBP it can be advantageous. In some patients with an SEP, surgery to remove the solitary
plasmacytoma is an option while some patients with an SBP may require orthopaedic surgery to provide bone stability.