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The term amyloidosis is a generic term used for a group of diseases where an abnormal protein is produced. The abnormal protein can build up in various organs or tissues and cause problems.
In AL amyloidosis, abnormal plasma cells in the bone marrow produce an abnormal protein called amyloid. This abnormal protein is only broken down very slowly by the body and starts to build up in the tissues and organs. The build up of amyloid in these tissues and organs gradually damages their function and causes symptoms. The build up of amyloid protein is called an ‘amyloid deposit’.
Amyloid deposits can build up almost anywhere in the body. Each patient has a different pattern of amyloid deposition, with different organs affected. Amyloid can build up in the kidneys, heart, liver, spleen, nerves, or digestive system, and may affect two or more organs at the same time. AL amyloidosis does not affect the brain.
AL amyloidosis is a relatively rare disease, with approximately 500 – 600 people diagnosed in the UK each year. Treatments for AL amyloidosis can be very effective at halting its progress. However there is currently no cure.
How We Can Help
AL amyloidosis Matters
A free AL amyloidosis specific newsletter distributed three times a year. AL amyloidosis Matters includes all the latest treatment and research news along with feature articles relevant to those affected by AL amyloidosis. Subscribe now
Patient and Family AL amyloidosis Infodays
Daytime events that allow you to hear about the latest treatments for AL amyloidosis direct from the experts. You will meet others affected by AL amyloidosis and have the opportunity to ask questions and share experiences in a relaxed setting. Find out more
Our Information Specialists can answer your questions about AL amyloidosis. Call 0800 980 3332 for information, practical advice, emotional support and a listening ear. Find out more
AL amyloidosis information
Provides information about AL amyloidosis, its treatment and management. Also includes information on a range of specific topics relating to living with AL amyloidosis, such as diet and nutrition, travel insurance and setting up a support group.
Amyloidosis Support Groups
A number of small, informal Support Groups for Amyloidosis Patients have been set up around the UK, providing the opportunity to meet up over coffee, chat and get to know one another. There are currently groups in Scotland, Manchester, Essex and London. For more information download our Support Group Infosheet where further information about the groups is listed on the final page.