Monoclonal Gammopathy of Undetermined Significance (MGUS) Infosheet

If you have been diagnosed with MGUS, this Infosheet will help you to understand what it is and how it is diagnosed and managed.

This Infosheet covers key questions and topics about MGUS, including:

• What is MGUS?
• What causes MGUS?
• How is MGUS diagnosed?
• How is MGUS monitored?
• Can MGUS change into another condition?
• Sources of support
• Medical terms explained

Key points you can read about in this Infosheet include:

• MGUS is a condition where abnormal plasma cells in the bone marrow produce a protein called a paraprotein
• MGUS is not a cancer
• MGUS normally has no symptoms and is not treated
• For a small number of people (1 in 100 each year), MGUS may change into a blood cancer or related condition, such as myeloma, lymphoma, or AL amyloidosis
• A combination of regular blood tests and symptom checks are used to monitor MGUS
• Report any change of symptoms or new symptoms to your healthcare team as soon as possible. Do not wait until your next appointment
• In most people, MGUS remains stable and has no effect on general health

We also have a Diary for people with MGUS. This offers a space to keep a record of your blood test results and space to write down any thoughts or questions you may have.

MGUS Infosheet

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